The Impact of Graphene Oxide on Polycaprolactone PCL Surfaces: Antimicrobial Activity and Osteogenic Differentiation of Mesenchymal Stem Cell

In dentistry, bone regeneration requires osteoinductive biomaterial with antibacterial properties. Polycaprolactone (PCL) may be combined different nanofillers including reduced graphene oxide (rGO). Here, the amount of rGO filler was defined to obtain a biocompatible and PCL-based surface supporting adhesion differentiation human mesenchymal stem cells (MSCs). Compounds carrying three percentages were tested. Among all, 5% rGO-PCL compound is most bacteriostatic against Gram-positive bacteria. All scaffolds are biocompatible. MSCs adhere proliferate on all scaffolds; however, supports growth implements expression extracellular matrix components necessary anchor itself. Moreover, has superior properties confirmed by improved alkaline phosphatase activity, mineral deposition, osteogenic markers expression. These results suggest that useful for tissue engineering purposes.